Frontotemporal dementia: From the clinic to the differential diagnosis

Introduction: Frontotemporal dementia (FTD) is a disease that encompasses several syndromes differ in their cognitive, behavioral, language signs, and motor phenomena. Only Alzheimer’s causes more early-onset cases than FTD. According to World Health Organization (WHO) projections, rates will double every 20 years reach 115.4 million people 2050, ranging from 3% 26%. The FTD spectrum three variant syndromes, namely the behavioral variant, semantic non-fluent/agrammatical variant. lobar degeneration neuropathologically related clinical phenotypes of Therefore, frontal temporal lobes suffer gliosis selective neuronal loss due this neurodegenerative condition. Case Report: A 62-year-old doctor with no comorbidities. family, he reports delivering very slowly, which doesn’t comes processing efficiently. He claims already lost on street but managed restore his visuospatial function. denies changes daily life recent trauma. Neurological examination revealed impaired attention changes, short-term memory (mini-mental: 19/30 points), normal laboratory, regular liquor; skull magnetic resonance imaging (MRI) showed mild atrophy frontotemporal regions. Decreased activity areas cortex was observed by cerebral perfusion scintigraphy. Conclusion: report relevant because it correlates patient neurological tests good indication FTD; however, diagnosis can be confirmed greater accuracy through brain It still possible observe although there has been significant increase literature FTD, its variants clinic need further studies regarding differential diagnoses, mainly psychiatric disorders